Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4643672..4644274 Replicon chromosome
Accession NZ_CP117365
Organism Salmonella enterica subsp. enterica serovar Newport strain RM089

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQP78_RS22690 Protein ID WP_001159630.1
Coordinates 4643963..4644274 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP78_RS22685 Protein ID WP_000362050.1
Coordinates 4643672..4643962 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP78_RS22670 (4641167) 4641167..4642069 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQP78_RS22675 (4642066) 4642066..4642699 + 634 Protein_4427 formate dehydrogenase cytochrome b556 subunit -
PQP78_RS22680 (4642696) 4642696..4643625 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP78_RS22685 (4643672) 4643672..4643962 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP78_RS22690 (4643963) 4643963..4644274 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP78_RS22695 (4644492) 4644492..4645421 + 930 WP_001127704.1 alpha/beta hydrolase -
PQP78_RS22700 (4645507) 4645507..4645817 + 311 Protein_4432 type II toxin-antitoxin system HigB family toxin -
PQP78_RS22705 (4645814) 4645814..4646260 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP78_RS22710 (4646275) 4646275..4647216 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP78_RS22715 (4647261) 4647261..4647698 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP78_RS22720 (4647695) 4647695..4648567 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP78_RS22725 (4648561) 4648561..4649160 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270841 WP_001159630.1 NZ_CP117365:c4644274-4643963 [Salmonella enterica subsp. enterica serovar Newport]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270841 WP_000362050.1 NZ_CP117365:c4643962-4643672 [Salmonella enterica subsp. enterica serovar Newport]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References