Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4140345..4140861 Replicon chromosome
Accession NZ_CP117365
Organism Salmonella enterica subsp. enterica serovar Newport strain RM089

Toxin (Protein)


Gene name relE Uniprot ID A0A0R9NWE9
Locus tag PQP78_RS20175 Protein ID WP_000220579.1
Coordinates 4140345..4140629 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQP78_RS20180 Protein ID WP_000212724.1
Coordinates 4140619..4140861 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP78_RS20160 (4135461) 4135461..4137113 + 1653 WP_000155055.1 alpha,alpha-phosphotrehalase -
PQP78_RS20165 (4137522) 4137522..4139660 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PQP78_RS20170 (4139877) 4139877..4140341 + 465 WP_001009175.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP78_RS20175 (4140345) 4140345..4140629 - 285 WP_000220579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP78_RS20180 (4140619) 4140619..4140861 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP78_RS20185 (4140939) 4140939..4142852 - 1914 WP_001212131.1 BglG family transcription antiterminator -
PQP78_RS20190 (4142869) 4142869..4143609 - 741 WP_000779247.1 KDGP aldolase family protein -
PQP78_RS20195 (4143606) 4143606..4144724 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP78_RS20200 (4144708) 4144708..4145841 - 1134 WP_274891857.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10884.70 Da        Isoelectric Point: 10.0482

>T270839 WP_000220579.1 NZ_CP117365:c4140629-4140345 [Salmonella enterica subsp. enterica serovar Newport]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDTNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270839 WP_000212724.1 NZ_CP117365:c4140861-4140619 [Salmonella enterica subsp. enterica serovar Newport]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NWE9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References