Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 836270..836895 Replicon chromosome
Accession NZ_CP117365
Organism Salmonella enterica subsp. enterica serovar Newport strain RM089

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PQP78_RS04035 Protein ID WP_000911337.1
Coordinates 836497..836895 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag PQP78_RS04030 Protein ID WP_000557545.1
Coordinates 836270..836497 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP78_RS04000 (831315) 831315..832832 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQP78_RS04005 (832908) 832908..833453 - 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
PQP78_RS04010 (833718) 833718..834476 + 759 WP_000244328.1 amidase activator ActS -
PQP78_RS04020 (834761) 834761..835567 - 807 WP_010989071.1 DUF1460 domain-containing protein -
PQP78_RS04025 (835842) 835842..836093 - 252 WP_001540858.1 hypothetical protein -
PQP78_RS04030 (836270) 836270..836497 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQP78_RS04035 (836497) 836497..836895 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQP78_RS04040 (837703) 837703..838239 + 537 WP_001038502.1 STM3031 family outer membrane protein -
PQP78_RS04045 (838286) 838286..838918 + 633 WP_000835265.1 YfdX family protein -
PQP78_RS04050 (839637) 839637..840218 + 582 WP_001244652.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 834761..844680 9919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T270830 WP_000911337.1 NZ_CP117365:836497-836895 [Salmonella enterica subsp. enterica serovar Newport]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT270830 WP_000557545.1 NZ_CP117365:836270-836497 [Salmonella enterica subsp. enterica serovar Newport]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References