Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 986877..987691 Replicon chromosome
Accession NZ_CP117354
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM099

Toxin (Protein)


Gene name TacT3 Uniprot ID M7RPS8
Locus tag PQP84_RS04730 Protein ID WP_000971649.1
Coordinates 986877..987404 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQP84_RS04735 Protein ID WP_000855694.1
Coordinates 987401..987691 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP84_RS04700 (983160) 983160..983558 + 399 Protein_920 cytoplasmic protein -
PQP84_RS04705 (983749) 983749..983988 + 240 Protein_921 hypothetical protein -
PQP84_RS04710 (984145) 984145..984813 + 669 WP_000445914.1 hypothetical protein -
PQP84_RS04715 (984840) 984840..985334 + 495 WP_000424948.1 hypothetical protein -
PQP84_RS04720 (985506) 985506..986162 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQP84_RS04725 (986395) 986395..986804 + 410 Protein_925 IS5/IS1182 family transposase -
PQP84_RS04730 (986877) 986877..987404 - 528 WP_000971649.1 GNAT family N-acetyltransferase Toxin
PQP84_RS04735 (987401) 987401..987691 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
PQP84_RS04740 (987961) 987961..988139 - 179 Protein_928 IS3 family transposase -
PQP84_RS04745 (988543) 988543..988986 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP84_RS04750 (989442) 989442..990092 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
PQP84_RS04755 (990089) 990089..991777 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 986664..986804 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(1-95)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19026.88 Da        Isoelectric Point: 9.3905

>T270744 WP_000971649.1 NZ_CP117354:c987404-986877 [Salmonella enterica subsp. enterica serovar Dublin]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp


Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT270744 WP_000855694.1 NZ_CP117354:c987691-987401 [Salmonella enterica subsp. enterica serovar Dublin]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3V5VVF5


Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References