Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4168325..4168841 Replicon chromosome
Accession NZ_CP117348
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain RM101

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag PQQ11_RS20270 Protein ID WP_000220577.1
Coordinates 4168325..4168609 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ11_RS20275 Protein ID WP_000212724.1
Coordinates 4168599..4168841 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ11_RS20255 (4163441) 4163441..4165093 + 1653 WP_000155047.1 alpha,alpha-phosphotrehalase -
PQQ11_RS20260 (4165502) 4165502..4167640 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ11_RS20265 (4167857) 4167857..4168321 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ11_RS20270 (4168325) 4168325..4168609 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ11_RS20275 (4168599) 4168599..4168841 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ11_RS20280 (4168919) 4168919..4170832 - 1914 WP_274897982.1 BglG family transcription antiterminator -
PQQ11_RS20285 (4170849) 4170849..4171589 - 741 WP_000779250.1 KDGP aldolase family protein -
PQQ11_RS20290 (4171586) 4171586..4172704 - 1119 WP_001139173.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ11_RS20295 (4172688) 4172688..4173821 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T270708 WP_000220577.1 NZ_CP117348:c4168609-4168325 [Salmonella enterica subsp. enterica serovar Heidelberg]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270708 WP_000212724.1 NZ_CP117348:c4168841-4168599 [Salmonella enterica subsp. enterica serovar Heidelberg]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References