Detailed information of TA system TA027070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 44599..45073
• Replicon: plasmid pSBAL11703
• Accession: NC_017578
• Organism: Shewanella baltica OS117

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A0A8F3ILQ2
• Locus tag: SBAL117_RS24475
• Protein ID: WP_011839957.1
• Coordinates: 44599..44865 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A8F3IL86
• Locus tag: SBAL117_RS24480
• Protein ID: WP_011839958.1
• Coordinates: 44849..45073 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL117_RS24450	41471..41815	-	345	WP_011839953.1	IS4 family transposase	-
SBAL117_RS24455	41864..42181	-	318	WP_011839954.1	recombination regulator RecX	-
SBAL117_RS24460	42178..43563	-	1386	WP_011839955.1	hypothetical protein	-
SBAL117_RS24470	44217..44606	-	390	WP_011839956.1	hypothetical protein	-
SBAL117_RS24475	44599..44865	-	267	WP_011839957.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SBAL117_RS24480	44849..45073	-	225	WP_011839958.1	TraY domain-containing protein	Antitoxin
SBAL117_RS25285	45151..45378	+	228	Protein_49	IS30 family transposase	-
SBAL117_RS24490	45594..45785	+	192	WP_014620453.1	hypothetical protein	-
SBAL117_RS25680	46114..46311	-	198	WP_014620454.1	hypothetical protein	-
SBAL117_RS24500	46308..46934	-	627	WP_011839960.1	hypothetical protein	-
SBAL117_RS25290	47486..47854	-	369	WP_011839961.1	hypothetical protein	-
SBAL117_RS24505	47882..49186	+	1305	WP_011839962.1	RNA-directed DNA polymerase	-
SBAL117_RS24510	49487..49822	-	336	WP_190272054.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..71173	71173

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Relaxosome protein TraY (4-45)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10355.11 Da
• Isoelectric Point: 9.7697

>T27070 WP_011839957.1 NC_017578:c44865-44599 [Shewanella baltica OS117]
MAWTIDYSERALKSLKKMDKQNAKRILDFLEQRIAILDDPRTSGKPLKGDLGIFWRYRVGDYRVLCEIQDSKLVILTALI
GHRKEIYE

Nucleotide

• Length: 267 bp

>T27070 NC_017578:c44865-44599 [Shewanella baltica OS117]
TTGGCTTGGACAATTGATTACTCAGAACGAGCGCTAAAATCACTAAAAAAAATGGATAAGCAGAACGCTAAACGCATTCT
GGATTTTTTGGAACAGCGCATAGCGATATTGGACGACCCGAGAACGTCAGGAAAGCCCCTGAAGGGGGATTTGGGTATTT
TTTGGCGTTATCGAGTCGGTGACTATCGAGTGCTTTGTGAAATTCAAGATAGCAAATTAGTCATTCTGACTGCTTTGATA
GGGCACAGGAAAGAGATCTATGAGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8303.30 Da
• Isoelectric Point: 4.4079

>AT27070 WP_011839958.1 NC_017578:c45073-44849 [Shewanella baltica OS117]
MLAIRLPDDIETRLAALADQTGRTKTFYAREAILTHLEDLEDYYLAAQIVSDIRKGAEKTYSSEDVRASLGLDN

Nucleotide

• Length: 225 bp

>AT27070 NC_017578:c45073-44849 [Shewanella baltica OS117]
ATGTTAGCAATACGGTTACCTGATGATATTGAAACCCGTCTGGCTGCTTTGGCAGATCAAACCGGTAGAACAAAAACCTT
TTACGCCAGAGAAGCTATTTTGACTCATTTAGAGGATCTGGAGGATTACTATCTTGCGGCTCAGATTGTCTCTGATATTC
GTAAAGGGGCTGAAAAAACCTACAGTAGCGAAGATGTGAGGGCGTCTCTTGGCTTGGACAATTGA