Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3545524..3546144 Replicon chromosome
Accession NZ_CP117346
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM104

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP85_RS17675 Protein ID WP_001280991.1
Coordinates 3545926..3546144 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP85_RS17670 Protein ID WP_000344807.1
Coordinates 3545524..3545898 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP85_RS17660 (3540663) 3540663..3541856 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP85_RS17665 (3541879) 3541879..3545028 + 3150 WP_052897443.1 efflux RND transporter permease AcrB -
PQP85_RS17670 (3545524) 3545524..3545898 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP85_RS17675 (3545926) 3545926..3546144 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP85_RS17680 (3546323) 3546323..3546874 + 552 WP_001278787.1 maltose O-acetyltransferase -
PQP85_RS17685 (3546992) 3546992..3547462 + 471 WP_000136183.1 YlaC family protein -
PQP85_RS17690 (3547518) 3547518..3547658 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP85_RS17695 (3547664) 3547664..3547924 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP85_RS17700 (3548149) 3548149..3549699 + 1551 WP_000213140.1 EAL domain-containing protein -
PQP85_RS17710 (3549930) 3549930..3550319 + 390 WP_000961287.1 MGMT family protein -
PQP85_RS17715 (3550352) 3550352..3550921 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270682 WP_001280991.1 NZ_CP117346:3545926-3546144 [Salmonella enterica subsp. enterica serovar Dublin]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270682 WP_000344807.1 NZ_CP117346:3545524-3545898 [Salmonella enterica subsp. enterica serovar Dublin]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References