Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4669466..4670068 Replicon chromosome
Accession NZ_CP117338
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM095

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQP94_RS22820 Protein ID WP_001159630.1
Coordinates 4669757..4670068 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP94_RS22815 Protein ID WP_000362050.1
Coordinates 4669466..4669756 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP94_RS22800 (4666959) 4666959..4667861 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQP94_RS22805 (4667858) 4667858..4668493 + 636 WP_274895786.1 formate dehydrogenase cytochrome b556 subunit -
PQP94_RS22810 (4668490) 4668490..4669419 + 930 WP_058685073.1 formate dehydrogenase accessory protein FdhE -
PQP94_RS22815 (4669466) 4669466..4669756 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP94_RS22820 (4669757) 4669757..4670068 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP94_RS22825 (4670286) 4670286..4671215 + 930 WP_001127703.1 alpha/beta hydrolase -
PQP94_RS22830 (4671301) 4671301..4671612 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQP94_RS22835 (4671609) 4671609..4672055 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP94_RS22840 (4672070) 4672070..4673011 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP94_RS22845 (4673056) 4673056..4673493 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PQP94_RS22850 (4673490) 4673490..4674362 - 873 WP_000921427.1 virulence factor BrkB family protein -
PQP94_RS22855 (4674356) 4674356..4674955 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270623 WP_001159630.1 NZ_CP117338:c4670068-4669757 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270623 WP_000362050.1 NZ_CP117338:c4669756-4669466 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References