Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4349079..4349860 | Replicon | chromosome |
| Accession | NZ_CP117338 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain RM095 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | PQP94_RS21395 | Protein ID | WP_000626099.1 |
| Coordinates | 4349079..4349570 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | PQP94_RS21400 | Protein ID | WP_001110452.1 |
| Coordinates | 4349567..4349860 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQP94_RS21360 (4345074) | 4345074..4345649 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| PQP94_RS21370 (4345920) | 4345920..4345997 | - | 78 | Protein_4178 | helix-turn-helix domain-containing protein | - |
| PQP94_RS21375 (4346088) | 4346088..4346420 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| PQP94_RS21380 (4346492) | 4346492..4346869 | + | 378 | WP_274895769.1 | EthD domain-containing protein | - |
| PQP94_RS21385 (4347902) | 4347902..4347976 | + | 75 | Protein_4181 | porin family protein | - |
| PQP94_RS21390 (4348079) | 4348079..4348831 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| PQP94_RS21395 (4349079) | 4349079..4349570 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| PQP94_RS21400 (4349567) | 4349567..4349860 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| PQP94_RS21405 (4350177) | 4350177..4350398 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| PQP94_RS21410 (4350663) | 4350663..4351538 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| PQP94_RS21415 (4351535) | 4351535..4351822 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| PQP94_RS21420 (4351845) | 4351845..4352060 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| PQP94_RS21425 (4352068) | 4352068..4352337 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| PQP94_RS21430 (4352631) | 4352631..4353536 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T270622 WP_000626099.1 NZ_CP117338:c4349570-4349079 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT270622 WP_001110452.1 NZ_CP117338:c4349860-4349567 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |