Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805614..806262 Replicon chromosome
Accession NZ_CP117290
Organism Salmonella enterica subsp. enterica serovar Typhi strain S6

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag PRW98_RS03910 Protein ID WP_000244762.1
Coordinates 805861..806262 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PRW98_RS03905 Protein ID WP_000351186.1
Coordinates 805614..805880 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW98_RS03885 (PRW98_03885) 801542..802975 - 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -
PRW98_RS03890 (PRW98_03890) 803134..803445 + 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
PRW98_RS03895 (PRW98_03895) 803609..804268 + 660 WP_000250289.1 hemolysin III family protein -
PRW98_RS03900 (PRW98_03900) 804384..805364 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
PRW98_RS03905 (PRW98_03905) 805614..805880 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PRW98_RS03910 (PRW98_03910) 805861..806262 + 402 WP_000244762.1 protein YgfX Toxin
PRW98_RS03915 (PRW98_03915) 806327..806848 - 522 WP_001055885.1 flavodoxin FldB -
PRW98_RS03920 (PRW98_03920) 806961..807857 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PRW98_RS03925 (PRW98_03925) 807881..808594 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PRW98_RS03930 (PRW98_03930) 808600..810333 + 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T270241 WP_000244762.1 NZ_CP117290:805861-806262 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270241 WP_000351186.1 NZ_CP117290:805614-805880 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References