Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3879286..3879813 Replicon chromosome
Accession NC_017564
Organism Yersinia enterocolitica subsp. palearctica Y11

Toxin (Protein)


Gene name relE Uniprot ID A0A7T9XW08
Locus tag Y11_RS17780 Protein ID WP_005166250.1
Coordinates 3879538..3879813 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7T9XW39
Locus tag Y11_RS17775 Protein ID WP_005166251.1
Coordinates 3879286..3879534 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y11_RS17755 3875886..3876980 + 1095 WP_005166255.1 LPS export ABC transporter permease LptF -
Y11_RS17760 3876980..3878050 + 1071 WP_005166254.1 LPS export ABC transporter permease LptG -
Y11_RS23020 3878347..3878855 - 509 Protein_3461 helix-turn-helix domain containing protein -
Y11_RS17770 3878916..3879209 + 294 Protein_3462 DUF4942 domain-containing protein -
Y11_RS17775 3879286..3879534 + 249 WP_005166251.1 ribbon-helix-helix domain-containing protein Antitoxin
Y11_RS17780 3879538..3879813 + 276 WP_005166250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Y11_RS17785 3879932..3880720 + 789 WP_005166249.1 helix-turn-helix domain-containing protein -
Y11_RS17790 3880948..3881079 + 132 Protein_3466 IS3 family transposase -
Y11_RS17795 3881133..3881858 - 726 WP_005180647.1 IS21-like element ISYen2A/ISYen2B family helper ATPase IstB -
Y11_RS17800 3881845..3883353 - 1509 WP_005180650.1 IS21-like element ISYen2A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10974.31 Da        Isoelectric Point: 4.5486

>T27022 WP_005166250.1 NC_017564:3879538-3879813 [Yersinia enterocolitica subsp. palearctica Y11]
MEIYWTLKAQDDLERIYCFALQYSRQHGDDVLDRLITGCAGLTAYPAIGVQQTRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T27022 NC_017564:3879538-3879813 [Yersinia enterocolitica subsp. palearctica Y11]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAGCGTATCTACTGTTTTGCCCTTCAGTACAGCCGCCAGCA
CGGCGATGACGTTTTGGATCGCCTGATTACAGGCTGTGCTGGTCTTACAGCGTATCCGGCAATTGGCGTACAGCAGACTC
GGTATGAACCTCGGGAAGTCCGAAAAGTGTTATTTGATGATTATGAGGTTCACTACGAACTTCGTGACAATGACATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9034.30 Da        Isoelectric Point: 6.4624

>AT27022 WP_005166251.1 NC_017564:3879286-3879534 [Yersinia enterocolitica subsp. palearctica Y11]
MGSLTKQTISAQIPVELATAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSDMVDFANRLK
QS

Download         Length: 249 bp

>AT27022 NC_017564:3879286-3879534 [Yersinia enterocolitica subsp. palearctica Y11]
ATGGGTTCGCTTACTAAACAAACTATCAGCGCACAGATACCTGTTGAGTTGGCTACTGCTGTTGAAAATCTGGCAATTGA
GTTAGATCGTTCTAAAAGTTGGATTATTAAGGAAGCGTTGACCAGTATGCTGGCCGAAAGAGAACGGCGTCACCAGAGCA
TCCAGGCCGGTCTCGCGGATGTGGATGCTGGTCGCGTGGTGAGCCACTCGGACATGGTAGATTTTGCTAATCGCTTAAAG
CAATCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9XW08

Antitoxin

Source ID Structure
AlphaFold DB A0A7T9XW39

References