Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4269356..4269614 Replicon chromosome
Accession NZ_CP117235
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PQQ28_RS21015 Protein ID WP_000809168.1
Coordinates 4269462..4269614 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4269356..4269413 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ28_RS21000 4265185..4266444 - 1260 WP_000494928.1 hypothetical protein -
PQQ28_RS21005 4266573..4268066 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
PQQ28_RS21010 4268086..4268847 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4269356..4269413 - 58 - - Antitoxin
PQQ28_RS21015 4269462..4269614 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
PQQ28_RS21020 4269719..4270849 - 1131 WP_001118465.1 molecular chaperone DnaJ -
PQQ28_RS21025 4270938..4272854 - 1917 WP_000516135.1 molecular chaperone DnaK -
PQQ28_RS21030 4273226..4273630 + 405 WP_000843687.1 DUF2541 family protein -
PQQ28_RS21035 4273656..4274369 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T270141 WP_000809168.1 NZ_CP117235:4269462-4269614 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT270141 NZ_CP117235:c4269413-4269356 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References