Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4190590..4192279 | Replicon | chromosome |
| Accession | NZ_CP117020 | ||
| Organism | Escherichia coli strain MLI106K3 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | V0Z9M0 |
| Locus tag | NL424_RS20405 | Protein ID | WP_000365809.1 |
| Coordinates | 4191359..4192279 (+) | Length | 307 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | NL424_RS20400 | Protein ID | WP_001550661.1 |
| Coordinates | 4190590..4191372 (+) | Length | 261 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL424_RS20380 (4185899) | 4185899..4186057 | - | 159 | Protein_3901 | integrase | - |
| NL424_RS20385 (4186149) | 4186149..4186251 | - | 103 | Protein_3902 | helix-turn-helix domain-containing protein | - |
| NL424_RS20390 (4186248) | 4186248..4186718 | - | 471 | WP_000201185.1 | hypothetical protein | - |
| NL424_RS20395 (4187065) | 4187065..4190274 | - | 3210 | WP_001521910.1 | RNA-directed DNA polymerase | - |
| NL424_RS20400 (4190590) | 4190590..4191372 | + | 783 | WP_001550661.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| NL424_RS20405 (4191359) | 4191359..4192279 | + | 921 | WP_000365809.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| NL424_RS20410 (4192713) | 4192713..4193597 | - | 885 | WP_001119037.1 | LysR family transcriptional regulator | - |
| NL424_RS20415 (4193862) | 4193862..4194920 | + | 1059 | WP_122987197.1 | alpha/beta hydrolase | - |
| NL424_RS20420 (4195062) | 4195062..4196189 | + | 1128 | WP_001550663.1 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC | 4186248..4232910 | 46662 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 34571.01 Da Isoelectric Point: 7.2649
>T269870 WP_000365809.1 NZ_CP117020:4191359-4192279 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA
Download Length: 921 bp
Antitoxin
Download Length: 261 a.a. Molecular weight: 29191.43 Da Isoelectric Point: 8.9059
>AT269870 WP_001550661.1 NZ_CP117020:4190590-4191372 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA
Download Length: 783 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|