Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 542053..542691 Replicon chromosome
Accession NZ_CP117020
Organism Escherichia coli strain MLI106K3

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NL424_RS03030 Protein ID WP_000813795.1
Coordinates 542053..542229 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NL424_RS03035 Protein ID WP_076797675.1
Coordinates 542275..542691 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL424_RS03010 (537675) 537675..538847 - 1173 WP_001551088.1 BenE family transporter YdcO -
NL424_RS03015 (538939) 538939..539475 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
NL424_RS03020 (539548) 539548..541509 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NL424_RS03025 (541601) 541601..541831 - 231 WP_023910283.1 YncJ family protein -
NL424_RS03030 (542053) 542053..542229 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NL424_RS03035 (542275) 542275..542691 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NL424_RS03040 (542770) 542770..544176 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
NL424_RS03045 (544421) 544421..545566 + 1146 WP_001551094.1 ABC transporter substrate-binding protein -
NL424_RS03050 (545584) 545584..546597 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
NL424_RS03055 (546598) 546598..547539 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T269854 WP_000813795.1 NZ_CP117020:542053-542229 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT269854 WP_076797675.1 NZ_CP117020:542275-542691 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References