Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3798382..3798640 Replicon chromosome
Accession NZ_CP117016
Organism Escherichia coli strain MLI121

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NL415_RS19210 Protein ID WP_000809168.1
Coordinates 3798382..3798534 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3798583..3798640 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL415_RS19190 3793624..3794337 - 714 WP_001102367.1 acidic protein MsyB -
NL415_RS19195 3794363..3794767 - 405 WP_000843579.1 DUF2541 family protein -
NL415_RS19200 3795143..3797059 + 1917 WP_000516135.1 molecular chaperone DnaK -
NL415_RS19205 3797148..3798278 + 1131 WP_001118464.1 molecular chaperone DnaJ -
NL415_RS19210 3798382..3798534 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3798583..3798640 + 58 - - Antitoxin
NL415_RS19215 3799120..3800286 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
NL415_RS19220 3800352..3801251 + 900 WP_001300855.1 transcriptional activator NhaR -
NL415_RS19225 3801289..3802248 - 960 WP_000871682.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T269842 WP_000809168.1 NZ_CP117016:c3798534-3798382 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT269842 NZ_CP117016:3798583-3798640 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References