Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3431773..3432391 Replicon chromosome
Accession NZ_CP117010
Organism Escherichia coli strain MLI110

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL413_RS17340 Protein ID WP_001291435.1
Coordinates 3432173..3432391 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL413_RS17335 Protein ID WP_000344800.1
Coordinates 3431773..3432147 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL413_RS17325 (3426862) 3426862..3428055 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL413_RS17330 (3428078) 3428078..3431227 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL413_RS17335 (3431773) 3431773..3432147 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL413_RS17340 (3432173) 3432173..3432391 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL413_RS17345 (3432563) 3432563..3433114 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL413_RS17350 (3433230) 3433230..3433700 + 471 WP_000136192.1 YlaC family protein -
NL413_RS17355 (3433864) 3433864..3435414 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL413_RS17360 (3435456) 3435456..3435809 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NL413_RS17370 (3436188) 3436188..3436499 + 312 WP_000409911.1 MGMT family protein -
NL413_RS17375 (3436530) 3436530..3437102 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269801 WP_001291435.1 NZ_CP117010:3432173-3432391 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269801 WP_000344800.1 NZ_CP117010:3431773-3432147 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References