Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 139192..139423 Replicon plasmid p140_MLI109
Accession NZ_CP117007
Organism Escherichia coli strain MLI109

Toxin (Protein)


Gene name srnB Uniprot ID A0A762TWR7
Locus tag NL412_RS00810 Protein ID WP_023144756.1
Coordinates 139289..139423 (+) Length 45 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 139192..139243 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL412_RS00790 (136722) 136722..137468 + 747 WP_000205736.1 conjugal transfer pilus acetylase TraX -
NL412_RS00795 (137523) 137523..138083 + 561 WP_000139341.1 fertility inhibition protein FinO -
NL412_RS00800 (138215) 138215..138427 + 213 WP_072042863.1 ANR family transcriptional regulator -
NL412_RS00805 (138939) 138939..139225 + 287 Protein_160 DUF2726 domain-containing protein -
- (139192) 139192..139243 - 52 NuclAT_1 - Antitoxin
- (139192) 139192..139243 - 52 NuclAT_1 - Antitoxin
- (139192) 139192..139243 - 52 NuclAT_1 - Antitoxin
- (139192) 139192..139243 - 52 NuclAT_1 - Antitoxin
NL412_RS00810 (139289) 139289..139423 + 135 WP_023144756.1 Hok/Gef family protein Toxin
NL412_RS00815 (139720) 139720..139974 + 255 WP_000083850.1 replication regulatory protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - agg3D / agg3C / agg3B / aap/aspU / pic 1..140278 140278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-44)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4896.90 Da        Isoelectric Point: 7.7209

>T269763 WP_023144756.1 NZ_CP117007:139289-139423 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFREQLCELNIHRGNTVVQVTLA

Download         Length: 135 bp

Antitoxin


Download         Length: 52 bp

>AT269763 NZ_CP117007:c139243-139192 [Escherichia coli]
TCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A762TWR7

Antitoxin

Download structure file

References