Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4690793..4691395 Replicon chromosome
Accession NZ_CP117006
Organism Escherichia coli strain MLI108K3

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NL411_RS24280 Protein ID WP_000897305.1
Coordinates 4691084..4691395 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL411_RS24275 Protein ID WP_000356395.1
Coordinates 4690793..4691083 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL411_RS24240 (4686417) 4686417..4687319 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NL411_RS24245 (4687316) 4687316..4687951 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NL411_RS24250 (4687948) 4687948..4688877 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NL411_RS24255 (4689059) 4689059..4689301 - 243 WP_001309881.1 CopG family transcriptional regulator -
NL411_RS24260 (4689520) 4689520..4689738 - 219 WP_001295676.1 CopG family transcriptional regulator -
NL411_RS24265 (4690157) 4690157..4690435 - 279 WP_001315112.1 hypothetical protein -
NL411_RS24270 (4690487) 4690487..4690708 - 222 WP_001550354.1 hypothetical protein -
NL411_RS24275 (4690793) 4690793..4691083 - 291 WP_000356395.1 NadS family protein Antitoxin
NL411_RS24280 (4691084) 4691084..4691395 - 312 WP_000897305.1 hypothetical protein Toxin
NL411_RS24285 (4691624) 4691624..4692532 + 909 WP_001550353.1 alpha/beta hydrolase -
NL411_RS24290 (4692700) 4692700..4693614 - 915 WP_109553727.1 transposase -
NL411_RS24295 (4693627) 4693627..4694514 - 888 Protein_4426 hypothetical protein -
NL411_RS24300 (4694930) 4694930..4695871 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NL411_RS24305 (4695916) 4695916..4696353 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T269756 WP_000897305.1 NZ_CP117006:c4691395-4691084 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT269756 WP_000356395.1 NZ_CP117006:c4691083-4690793 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References