Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3659677..3660331 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag PO910_RS17685 Protein ID WP_000244772.1
Coordinates 3659677..3660084 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PO910_RS17690 Protein ID WP_000354046.1
Coordinates 3660065..3660331 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS17665 (3655634) 3655634..3657367 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
PO910_RS17670 (3657373) 3657373..3658083 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PO910_RS17675 (3658108) 3658108..3659004 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PO910_RS17680 (3659116) 3659116..3659637 + 522 WP_001055874.1 flavodoxin FldB -
PO910_RS17685 (3659677) 3659677..3660084 - 408 WP_000244772.1 protein YgfX Toxin
PO910_RS17690 (3660065) 3660065..3660331 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PO910_RS17695 (3660574) 3660574..3661554 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PO910_RS17700 (3661631) 3661631..3662290 - 660 WP_000250274.1 hemolysin III family protein -
PO910_RS17705 (3662454) 3662454..3662765 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
PO910_RS17710 (3662810) 3662810..3664243 + 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
PO910_RS17715 (3664300) 3664300..3665043 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T269634 WP_000244772.1 NZ_CP116981:c3660084-3659677 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT269634 WP_000354046.1 NZ_CP116981:c3660331-3660065 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References