Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3304969..3305587 Replicon chromosome
Accession NZ_CP116929
Organism Escherichia coli strain MLI105

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL421_RS16385 Protein ID WP_001291435.1
Coordinates 3305369..3305587 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL421_RS16380 Protein ID WP_000344800.1
Coordinates 3304969..3305343 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL421_RS16370 (3300058) 3300058..3301251 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL421_RS16375 (3301274) 3301274..3304423 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL421_RS16380 (3304969) 3304969..3305343 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL421_RS16385 (3305369) 3305369..3305587 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL421_RS16390 (3305759) 3305759..3306310 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL421_RS16395 (3306426) 3306426..3306896 + 471 WP_000136192.1 YlaC family protein -
NL421_RS16400 (3307060) 3307060..3308610 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL421_RS16405 (3308652) 3308652..3309005 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NL421_RS16415 (3309384) 3309384..3309695 + 312 WP_000409911.1 MGMT family protein -
NL421_RS16420 (3309726) 3309726..3310298 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269486 WP_001291435.1 NZ_CP116929:3305369-3305587 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269486 WP_000344800.1 NZ_CP116929:3304969-3305343 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References