Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 697459..698152 Replicon chromosome
Accession NZ_CP116923
Organism Escherichia coli strain MLI104K1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NL419_RS03880 Protein ID WP_000415584.1
Coordinates 697459..697755 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NL419_RS03885 Protein ID WP_000650107.1
Coordinates 697757..698152 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL419_RS03845 (692547) 692547..692861 - 315 WP_000958598.1 putative quinol monooxygenase -
NL419_RS03850 (692892) 692892..693473 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NL419_RS03855 (693792) 693792..694124 + 333 WP_000917684.1 DUF2645 family protein -
NL419_RS03860 (694170) 694170..695519 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NL419_RS03865 (695516) 695516..696175 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NL419_RS03870 (696327) 696327..696719 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NL419_RS03875 (696772) 696772..697254 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NL419_RS03880 (697459) 697459..697755 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NL419_RS03885 (697757) 697757..698152 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NL419_RS03890 (698285) 698285..699892 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NL419_RS03895 (700030) 700030..702288 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T269430 WP_000415584.1 NZ_CP116923:697459-697755 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT269430 WP_000650107.1 NZ_CP116923:697757-698152 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References