Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 240190..240832 Replicon chromosome
Accession NZ_CP116889
Organism Bacillus anthracis strain AN17-384_2

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag PP184_RS01340 Protein ID WP_000635963.1
Coordinates 240482..240832 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag PP184_RS01335 Protein ID WP_000004570.1
Coordinates 240190..240477 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PP184_RS01310 (PP184_01310) 235506..236468 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
PP184_RS01315 (PP184_01315) 236461..237033 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
PP184_RS01320 (PP184_01320) 237126..237485 + 360 WP_000635040.1 holo-ACP synthase -
PP184_RS01325 (PP184_01325) 237642..238592 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
PP184_RS01330 (PP184_01330) 238711..239880 + 1170 WP_000390596.1 alanine racemase -
PP184_RS01335 (PP184_01335) 240190..240477 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
PP184_RS01340 (PP184_01340) 240482..240832 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
PP184_RS01345 (PP184_01345) 240900..243068 + 2169 WP_000426225.1 Tex family protein -
PP184_RS01350 (PP184_01350) 243126..243242 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
PP184_RS01355 (PP184_01355) 243438..243896 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T269304 WP_000635963.1 NZ_CP116889:240482-240832 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT269304 WP_000004570.1 NZ_CP116889:240190-240477 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References