Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2970130..2970778 Replicon chromosome
Accession NC_017524
Organism Mycobacterium tuberculosis CTRI-2

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag MTCTRI2_RS14015 Protein ID WP_003899414.1
Coordinates 2970130..2970453 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag MTCTRI2_RS14020 Protein ID WP_003899415.1
Coordinates 2970533..2970778 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTCTRI2_RS13985 2965453..2966451 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
MTCTRI2_RS13990 2966465..2966929 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
MTCTRI2_RS13995 2966917..2967168 + 252 WP_003908028.1 hypothetical protein -
MTCTRI2_RS14000 2967339..2968778 - 1440 WP_003899411.1 phage major capsid protein -
MTCTRI2_RS14005 2968786..2969319 - 534 WP_003899412.1 HK97 family phage prohead protease -
MTCTRI2_RS21530 2969472..2969963 - 492 WP_003900541.1 phage terminase small subunit P27 family -
MTCTRI2_RS14015 2970130..2970453 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
MTCTRI2_RS14020 2970533..2970778 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
MTCTRI2_RS14025 2970775..2972202 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
MTCTRI2_RS14030 2972204..2972596 - 393 WP_003899417.1 DUF2742 domain-containing protein -
MTCTRI2_RS14035 2972593..2972853 - 261 WP_014585547.1 helix-turn-helix domain-containing protein -
MTCTRI2_RS14040 2972870..2973232 - 363 WP_003900543.1 hypothetical protein -
MTCTRI2_RS14045 2973235..2974362 - 1128 WP_003899420.1 site-specific integrase -
MTCTRI2_RS14050 2974507..2974734 - 228 WP_003899421.1 hypothetical protein -
MTCTRI2_RS21535 2974731..2975120 - 390 WP_003899422.1 hypothetical protein -
MTCTRI2_RS14055 2975026..2975298 + 273 WP_003900544.1 hypothetical protein -
MTCTRI2_RS14060 2975397..2975630 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2965453..2974362 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T26928 WP_003899414.1 NC_017524:c2970453-2970130 [Mycobacterium tuberculosis CTRI-2]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T26928 NC_017524:c2970453-2970130 [Mycobacterium tuberculosis CTRI-2]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT26928 WP_003899415.1 NC_017524:c2970778-2970533 [Mycobacterium tuberculosis CTRI-2]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT26928 NC_017524:c2970778-2970533 [Mycobacterium tuberculosis CTRI-2]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References