Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2631257..2631594 Replicon chromosome
Accession NZ_CP116569
Organism Enterococcus faecalis strain K198-1

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag PML91_RS12515 Protein ID WP_002396786.1
Coordinates 2631257..2631400 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2631332..2631594 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML91_RS12495 2626534..2627166 - 633 WP_002358972.1 RloB family protein -
PML91_RS12500 2627175..2628470 - 1296 WP_176944748.1 ATP-binding protein -
PML91_RS12505 2628932..2630548 + 1617 WP_002406969.1 phosphatase PAP2/LCP family protein -
PML91_RS12510 2630883..2631026 + 144 WP_002367458.1 type I toxin-antitoxin system toxin PepG1 -
PML91_RS12515 2631257..2631400 + 144 WP_002396786.1 putative holin-like toxin Toxin
- 2631332..2631594 - 263 - - Antitoxin
PML91_RS12520 2631595..2636286 - 4692 WP_231432885.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T268994 WP_002396786.1 NZ_CP116569:2631257-2631400 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT268994 NZ_CP116569:c2631594-2631332 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTACTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References