Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1014509..1015043 Replicon chromosome
Accession NZ_CP116489
Organism Haemophilus influenzae strain 93P28H1

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag BV189_RS05045 Protein ID WP_005651512.1
Coordinates 1014509..1014799 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag BV189_RS05050 Protein ID WP_005651514.1
Coordinates 1014789..1015043 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV189_RS05020 (BV189_1020) 1011711..1012214 + 504 WP_005659127.1 LPS assembly lipoprotein LptE -
BV189_RS05025 (BV189_1021) 1012214..1013248 + 1035 WP_005659128.1 DNA polymerase III subunit delta -
BV189_RS05030 (BV189_1022) 1013427..1013729 + 303 WP_272524418.1 hypothetical protein -
BV189_RS05035 (BV189_1023) 1013912..1014049 - 138 WP_005659136.1 hypothetical protein -
BV189_RS05040 (BV189_1025) 1014219..1014473 - 255 WP_014551014.1 hypothetical protein -
BV189_RS05045 (BV189_1026) 1014509..1014799 - 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV189_RS05050 (BV189_1027) 1014789..1015043 - 255 WP_005651514.1 stability protein StbD Antitoxin
BV189_RS05055 (BV189_1028) 1015341..1015565 - 225 WP_005659141.1 hypothetical protein -
BV189_RS05060 (BV189_1029) 1015565..1015873 - 309 WP_005659142.1 P2 family phage major capsid protein -
BV189_RS05065 (BV189_1030) 1015903..1016442 - 540 WP_005659144.1 hypothetical protein -
BV189_RS05075 (BV189_1032) 1016804..1018870 - 2067 WP_005686190.1 glycine--tRNA ligase subunit beta -
BV189_RS05080 (BV189_1033) 1019208..1019573 - 366 WP_005686191.1 endonuclease domain-containing protein -
BV189_RS05085 (BV189_1034) 1019603..1019863 - 261 WP_005663579.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T268775 WP_005651512.1 NZ_CP116489:c1014799-1014509 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT268775 WP_005651514.1 NZ_CP116489:c1015043-1014789 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References