Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 155082..155339 Replicon chromosome
Accession NZ_CP116411
Organism Escherichia coli strain HH45

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag PL330_RS00700 Protein ID WP_001135738.1
Coordinates 155187..155339 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 155082..155136 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL330_RS00680 150307..151302 - 996 WP_001182653.1 O-acetyltransferase WecH -
PL330_RS00685 151477..151776 + 300 WP_000980111.1 YsaB family lipoprotein -
PL330_RS00690 151871..152782 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
PL330_RS00695 152792..154861 + 2070 WP_001291774.1 glycine--tRNA ligase subunit beta -
- 155082..155136 - 55 - - Antitoxin
PL330_RS00700 155187..155339 + 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
PL330_RS00705 155328..155387 - 60 WP_212591412.1 hypothetical protein -
PL330_RS00710 155527..155739 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PL330_RS00715 156020..156310 - 291 WP_000455798.1 HTH-type transcriptional regulator -
PL330_RS00720 156744..157454 + 711 WP_000190517.1 DUF3053 domain-containing protein -
PL330_RS00725 157504..158478 - 975 WP_000805027.1 glyoxylate/hydroxypyruvate reductase GhrB -
PL330_RS00730 158582..159241 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T268680 WP_001135738.1 NZ_CP116411:155187-155339 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T268680 NZ_CP116411:155187-155339 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT268680 NZ_CP116411:c155136-155082 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References