Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 222535..223340 Replicon plasmid unnamed1
Accession NZ_CP116348
Organism Enterobacter ludwigii strain CM-TZ4

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag PHA72_RS26650 Protein ID WP_221696624.1
Coordinates 222535..223062 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag PHA72_RS26655 Protein ID WP_139566909.1
Coordinates 223062..223340 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA72_RS26635 (PHA72_26630) 219489..219881 - 393 WP_000341066.1 hypothetical protein -
PHA72_RS26640 (PHA72_26635) 220231..220935 + 705 WP_001067848.1 IS6-like element IS26 family transposase -
PHA72_RS26645 (PHA72_26640) 221233..222423 + 1191 WP_265217072.1 DNA cytosine methyltransferase -
PHA72_RS26650 (PHA72_26645) 222535..223062 - 528 WP_221696624.1 GNAT family N-acetyltransferase Toxin
PHA72_RS26655 (PHA72_26650) 223062..223340 - 279 WP_139566909.1 DUF1778 domain-containing protein Antitoxin
PHA72_RS26660 (PHA72_26655) 223746..225311 + 1566 WP_221696623.1 ATP-binding protein -
PHA72_RS26665 (PHA72_26660) 225634..226191 + 558 WP_265217081.1 hypothetical protein -
PHA72_RS26670 (PHA72_26665) 226536..226778 + 243 WP_265217173.1 hypothetical protein -
PHA72_RS26675 (PHA72_26670) 226810..227202 + 393 WP_221696646.1 hypothetical protein -
PHA72_RS26680 (PHA72_26675) 227297..227971 + 675 WP_265217083.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-9 / aph(3'')-Ib / aph(6)-Id - 1..296144 296144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19191.06 Da        Isoelectric Point: 9.5209

>T268615 WP_221696624.1 NZ_CP116348:c223062-222535 [Enterobacter ludwigii]
MALTVPSALAAGHVLDEFDCGKGSLNDWLVRHARQSQSSGSAKTYVVTDDQRVVGYFSLTVGQIDTLEAPDRVRKGMGGY
PVPVVILARLAVDQRMHGRGIGVGLLQEAIRRTVIISEQAGVRAMLTHPIDDEAARFYHRFGFEASPVREQQLLLLLKDA
RKLLLPQSAQTRSIS

Download         Length: 528 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10078.39 Da        Isoelectric Point: 7.2022

>AT268615 WP_139566909.1 NZ_CP116348:c223340-223062 [Enterobacter ludwigii]
MGTSAMKTARFGLRATPQQEAVLRRAADVAHKSMTDFILDSAYQVAEQTLLDQRLFVVSGSQSHALLDLLDRPAQDNAGL
KDLFSRSAPWSS

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References