Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1104278..1104898 Replicon chromosome
Accession NZ_CP116347
Organism Enterobacter ludwigii strain CM-TZ4

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag PHA72_RS05495 Protein ID WP_014168902.1
Coordinates 1104278..1104496 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag PHA72_RS05500 Protein ID WP_020885187.1
Coordinates 1104524..1104898 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA72_RS05465 (PHA72_05465) 1100289..1100549 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
PHA72_RS05470 (PHA72_05470) 1100552..1100692 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PHA72_RS05475 (PHA72_05475) 1100689..1101399 - 711 WP_014168897.1 GNAT family protein -
PHA72_RS05480 (PHA72_05480) 1101500..1102960 + 1461 WP_059305810.1 PLP-dependent aminotransferase family protein -
PHA72_RS05485 (PHA72_05485) 1102932..1103399 - 468 WP_059305809.1 YlaC family protein -
PHA72_RS05490 (PHA72_05490) 1103517..1104068 - 552 WP_020885188.1 maltose O-acetyltransferase -
PHA72_RS05495 (PHA72_05495) 1104278..1104496 - 219 WP_014168902.1 HHA domain-containing protein Toxin
PHA72_RS05500 (PHA72_05500) 1104524..1104898 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
PHA72_RS05505 (PHA72_05505) 1105410..1108556 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit AcrB -
PHA72_RS05510 (PHA72_05510) 1108579..1109772 - 1194 WP_032677536.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T268606 WP_014168902.1 NZ_CP116347:c1104496-1104278 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT268606 WP_020885187.1 NZ_CP116347:c1104898-1104524 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References