Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 483320..483836 Replicon chromosome
Accession NZ_CP116347
Organism Enterobacter ludwigii strain CM-TZ4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PHA72_RS02305 Protein ID WP_059306429.1
Coordinates 483552..483836 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A839BTQ9
Locus tag PHA72_RS02300 Protein ID WP_020885404.1
Coordinates 483320..483562 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA72_RS02285 (PHA72_02285) 479317..480057 + 741 WP_059306432.1 KDGP aldolase family protein -
PHA72_RS02290 (PHA72_02290) 480176..481312 + 1137 WP_059306431.1 lactonase family protein -
PHA72_RS02295 (PHA72_02295) 481332..483242 + 1911 WP_059306430.1 PRD domain-containing protein -
PHA72_RS02300 (PHA72_02300) 483320..483562 + 243 WP_020885404.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PHA72_RS02305 (PHA72_02305) 483552..483836 + 285 WP_059306429.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PHA72_RS02310 (PHA72_02310) 483840..484304 - 465 WP_059306428.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PHA72_RS02315 (PHA72_02315) 484443..486581 - 2139 WP_059306427.1 anaerobic ribonucleoside-triphosphate reductase -
PHA72_RS02320 (PHA72_02320) 486949..487521 - 573 WP_059306426.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10950.73 Da        Isoelectric Point: 10.1619

>T268605 WP_059306429.1 NZ_CP116347:483552-483836 [Enterobacter ludwigii]
MTYELVFDPRAFKEWTRLGDTVKNQFKKKLANVLVNPWVESARLHGLPDCDKIKLRSQGYRLVYQVQDNVVTVCVITIGK
REKSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9085.49 Da        Isoelectric Point: 5.1088

>AT268605 WP_020885404.1 NZ_CP116347:483320-483562 [Enterobacter ludwigii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTVRERLANPQKGIKVRLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A839BTQ9

References