Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2050056..2050649 Replicon chromosome
Accession NZ_CP116246
Organism Desulfovibrio vulgaris strain L2

Toxin (Protein)


Gene name higB Uniprot ID Q72BA7
Locus tag PH214_RS09230 Protein ID WP_010939017.1
Coordinates 2050371..2050649 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PH214_RS09225 Protein ID WP_010939018.1
Coordinates 2050056..2050361 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH214_RS09215 (PH214_09215) 2045314..2046222 - 909 WP_271370175.1 type II CRISPR-associated endonuclease Cas1 -
PH214_RS09220 (PH214_09220) 2046234..2049428 - 3195 WP_271370176.1 type II CRISPR RNA-guided endonuclease Cas9 -
PH214_RS09225 (PH214_09225) 2050056..2050361 - 306 WP_010939018.1 HigA family addiction module antitoxin Antitoxin
PH214_RS09230 (PH214_09230) 2050371..2050649 - 279 WP_010939017.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PH214_RS09235 (PH214_09235) 2050920..2051336 + 417 WP_271370177.1 structural protein -
PH214_RS09240 (PH214_09240) 2051336..2051686 + 351 WP_271370178.1 hypothetical protein -
PH214_RS09245 (PH214_09245) 2051683..2051931 + 249 WP_271370179.1 hypothetical protein -
PH214_RS09250 (PH214_09250) 2052067..2052675 + 609 WP_271370180.1 hypothetical protein -
PH214_RS09255 (PH214_09255) 2052662..2054266 + 1605 WP_271370181.1 hypothetical protein -
PH214_RS09260 (PH214_09260) 2054263..2054817 + 555 WP_271370182.1 hypothetical protein -
PH214_RS09265 (PH214_09265) 2054814..2055155 + 342 WP_271370183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10558.00 Da        Isoelectric Point: 7.8928

>T268546 WP_010939017.1 NZ_CP116246:c2050649-2050371 [Desulfovibrio vulgaris]
MIASFRCKETRSLFDGGTSRRFQAFSAVALRKLDMLDAAVSLDDLRIPPANRLEALKGDRQGQHSIRINDQWRVCFVWRD
GAPHDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10893.47 Da        Isoelectric Point: 9.2414

>AT268546 WP_010939018.1 NZ_CP116246:c2050361-2050056 [Desulfovibrio vulgaris]
MRIRTHPGEVLNEEFLKPLGVTAHALAVALGVPATRIADIVHQRRGVSADTAARLARFFGTSAAFWMNLQSAYDLSIVER
DKGADLSHIRPHASVGTSLSC

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q72BA7

Antitoxin

Source ID Structure

References