Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 692003..692261 Replicon chromosome
Accession NZ_CP116194
Organism Escherichia coli strain DETEC-E1005

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PIB63_RS03365 Protein ID WP_000809168.1
Coordinates 692003..692155 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 692204..692261 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB63_RS03345 687248..687961 - 714 WP_001102391.1 acidic protein MsyB -
PIB63_RS03350 687987..688391 - 405 WP_000843687.1 DUF2541 family protein -
PIB63_RS03355 688763..690679 + 1917 WP_000516135.1 molecular chaperone DnaK -
PIB63_RS03360 690768..691898 + 1131 WP_001118464.1 molecular chaperone DnaJ -
PIB63_RS03365 692003..692155 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 692204..692261 + 58 - - Antitoxin
PIB63_RS03370 692770..693531 + 762 WP_001274832.1 outer membrane protein OmpK -
PIB63_RS03375 693551..695044 + 1494 WP_001774152.1 sulfatase-like hydrolase/transferase -
PIB63_RS03380 695173..696432 + 1260 WP_000494929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T268393 WP_000809168.1 NZ_CP116194:c692155-692003 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT268393 NZ_CP116194:692204-692261 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References