Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 612156..612568 Replicon chromosome
Accession NZ_CP116194
Organism Escherichia coli strain DETEC-E1005

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag PIB63_RS02965 Protein ID WP_000132614.1
Coordinates 612156..612497 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 612492..612568 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB63_RS02940 (607225) 607225..608505 - 1281 WP_001338077.1 DUF445 domain-containing protein -
PIB63_RS02945 (608690) 608690..609610 + 921 WP_001513532.1 Rpn family recombination-promoting nuclease/putative transposase -
PIB63_RS02950 (609838) 609838..609918 + 81 WP_020233658.1 hypothetical protein -
PIB63_RS02955 (610016) 610016..610892 + 877 Protein_573 DUF262 domain-containing protein -
PIB63_RS02960 (610946) 610946..612109 + 1164 WP_224153787.1 DUF1524 domain-containing protein -
PIB63_RS02965 (612156) 612156..612497 - 342 WP_000132614.1 endoribonuclease SymE Toxin
- (612492) 612492..612568 + 77 NuclAT_8 - Antitoxin
- (612492) 612492..612568 + 77 NuclAT_8 - Antitoxin
- (612492) 612492..612568 + 77 NuclAT_8 - Antitoxin
- (612492) 612492..612568 + 77 NuclAT_8 - Antitoxin
- (612492) 612492..612568 + 77 NuclAT_9 - Antitoxin
- (612492) 612492..612568 + 77 NuclAT_9 - Antitoxin
- (612492) 612492..612568 + 77 NuclAT_9 - Antitoxin
- (612492) 612492..612568 + 77 NuclAT_9 - Antitoxin
PIB63_RS02970 (612718) 612718..614487 - 1770 WP_001513535.1 restriction endonuclease subunit S -
PIB63_RS02975 (614487) 614487..615956 - 1470 WP_001387312.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T268389 WP_000132614.1 NZ_CP116194:c612497-612156 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT268389 NZ_CP116194:612492-612568 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References