Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4344161..4344756 Replicon chromosome
Accession NZ_CP116181
Organism Escherichia coli strain DETEC-E480

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag PIB86_RS21360 Protein ID WP_000239579.1
Coordinates 4344161..4344511 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag PIB86_RS21365 Protein ID WP_001223208.1
Coordinates 4344505..4344756 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB86_RS21340 (4339607) 4339607..4340629 - 1023 WP_001296689.1 ABC transporter permease -
PIB86_RS21345 (4340643) 4340643..4342145 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
PIB86_RS21350 (4342285) 4342285..4343241 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PIB86_RS21355 (4343551) 4343551..4344081 + 531 WP_000055075.1 inorganic diphosphatase -
PIB86_RS21360 (4344161) 4344161..4344511 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
PIB86_RS21365 (4344505) 4344505..4344756 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PIB86_RS21370 (4344968) 4344968..4345309 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
PIB86_RS21375 (4345312) 4345312..4349091 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T268321 WP_000239579.1 NZ_CP116181:c4344511-4344161 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT268321 WP_001223208.1 NZ_CP116181:c4344756-4344505 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References