Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4349306..4349828 Replicon chromosome
Accession NZ_CP116123
Organism Escherichia coli strain DETEC-P666

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag PIB57_RS20630 Protein ID WP_001105433.1
Coordinates 4349306..4349596 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag PIB57_RS20635 Protein ID WP_000212715.1
Coordinates 4349586..4349828 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB57_RS20615 (4344474) 4344474..4346129 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
PIB57_RS20620 (4346523) 4346523..4348661 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
PIB57_RS20625 (4348841) 4348841..4349305 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PIB57_RS20630 (4349306) 4349306..4349596 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIB57_RS20635 (4349586) 4349586..4349828 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PIB57_RS20640 (4350020) 4350020..4350406 - 387 WP_001232246.1 cytochrome b562 -
PIB57_RS20645 (4350589) 4350589..4351941 - 1353 WP_001162173.1 metalloprotease PmbA -
PIB57_RS20650 (4352035) 4352035..4352586 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
PIB57_RS20655 (4352736) 4352736..4354109 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T268103 WP_001105433.1 NZ_CP116123:c4349596-4349306 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT268103 WP_000212715.1 NZ_CP116123:c4349828-4349586 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References