Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 45724..46249 | Replicon | plasmid pDETEC15 |
Accession | NZ_CP116118 | ||
Organism | Escherichia coli strain DETEC-P793 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | V0SSI5 |
Locus tag | PIC92_RS26385 | Protein ID | WP_001159868.1 |
Coordinates | 45724..46029 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1PPD8 |
Locus tag | PIC92_RS26390 | Protein ID | WP_000813634.1 |
Coordinates | 46031..46249 (-) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PIC92_RS26370 (PIC92_26375) | 41634..42800 | - | 1167 | WP_000772446.1 | plasmid-partitioning protein SopA | - |
PIC92_RS26375 (PIC92_26380) | 43388..44143 | - | 756 | WP_000852146.1 | replication initiation protein RepE | - |
PIC92_RS26380 (PIC92_26385) | 44917..45723 | - | 807 | WP_000016982.1 | site-specific integrase | - |
PIC92_RS26385 (PIC92_26390) | 45724..46029 | - | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
PIC92_RS26390 (PIC92_26395) | 46031..46249 | - | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
PIC92_RS26395 (PIC92_26400) | 46816..47328 | + | 513 | WP_000151784.1 | hypothetical protein | - |
PIC92_RS26400 (PIC92_26405) | 47362..48495 | - | 1134 | WP_001542067.1 | DUF3800 domain-containing protein | - |
PIC92_RS26405 (PIC92_26410) | 48662..49435 | - | 774 | WP_000905949.1 | hypothetical protein | - |
PIC92_RS26410 (PIC92_26415) | 49448..49948 | - | 501 | WP_001773886.1 | HEPN family nuclease | - |
PIC92_RS26415 (PIC92_26420) | 50213..50443 | + | 231 | WP_001261278.1 | type II toxin-antitoxin system VapB family antitoxin | - |
PIC92_RS26420 (PIC92_26425) | 50440..50856 | + | 417 | WP_001034046.1 | type II toxin-antitoxin system VapC family toxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | senB | 1..82761 | 82761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11706.51 Da Isoelectric Point: 6.4674
>T268081 WP_001159868.1 NZ_CP116118:c46029-45724 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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