Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 264301..264932 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag PIC05_RS01200 Protein ID WP_001259385.1
Coordinates 264301..264576 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag PIC05_RS01205 Protein ID WP_000593554.1
Coordinates 264573..264932 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS01185 (259305) 259305..260372 + 1068 WP_000361467.1 HlyD family secretion protein -
PIC05_RS01190 (260369) 260369..263104 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
PIC05_RS01195 (263104) 263104..264228 + 1125 WP_001314210.1 ABC transporter permease -
PIC05_RS01200 (264301) 264301..264576 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
PIC05_RS01205 (264573) 264573..264932 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PIC05_RS01210 (264982) 264982..265842 - 861 WP_001131782.1 class II aldolase -
PIC05_RS01215 (265874) 265874..266143 - 270 WP_000933060.1 HPr family phosphocarrier protein -
PIC05_RS01220 (266133) 266133..267641 - 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
PIC05_RS01225 (267634) 267634..268992 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
PIC05_RS01230 (269069) 269069..269350 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
PIC05_RS01235 (269347) 269347..269820 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 256684..271191 14507


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T267984 WP_001259385.1 NZ_CP116106:264301-264576 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT267984 WP_000593554.1 NZ_CP116106:264573-264932 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References