Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 254673..255310 Replicon chromosome
Accession NC_017452
Organism Haemophilus influenzae R2846

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag R2846_RS01310 Protein ID WP_005659980.1
Coordinates 254673..255077 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag R2846_RS01315 Protein ID WP_005656316.1
Coordinates 255074..255310 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R2846_RS01280 250231..250797 + 567 WP_005544066.1 elongation factor P -
R2846_RS01290 251149..251736 - 588 WP_014550467.1 primosomal replication protein -
R2846_RS01295 251769..253121 - 1353 WP_014550468.1 Na+/H+ antiporter family protein -
R2846_RS01300 253436..254125 - 690 WP_005659978.1 ribonuclease T -
R2846_RS01305 254199..254606 - 408 WP_014550469.1 lactoylglutathione lyase -
R2846_RS01310 254673..255077 - 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
R2846_RS01315 255074..255310 - 237 WP_005656316.1 antitoxin Antitoxin
R2846_RS01320 255403..256128 - 726 WP_014550471.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
R2846_RS01325 256181..256699 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
R2846_RS01330 256918..258684 + 1767 WP_014550472.1 aspartate--tRNA ligase -
R2846_RS01335 258706..259182 + 477 WP_005686755.1 dihydroneopterin triphosphate diphosphatase -
R2846_RS01340 259342..260082 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T26796 WP_005659980.1 NC_017452:c255077-254673 [Haemophilus influenzae R2846]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T26796 NC_017452:c255077-254673 [Haemophilus influenzae R2846]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT26796 WP_005656316.1 NC_017452:c255310-255074 [Haemophilus influenzae R2846]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT26796 NC_017452:c255310-255074 [Haemophilus influenzae R2846]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAAGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References