Detailed information of TA system TA267942

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3183554..3183810
• Replicon: chromosome
• Accession: NZ_CP116100
• Organism: Escherichia coli strain DETEC-P881

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: PIC52_RS15350
• Protein ID: WP_001135731.1
• Coordinates: 3183658..3183810 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3183554..3183608 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PIC52_RS15330	3178782..3179777	-	996	WP_001606408.1	O-acetyltransferase WecH	-
PIC52_RS15335	3179952..3180251	+	300	WP_000980102.1	YsaB family lipoprotein	-
PIC52_RS15340	3180346..3181257	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
PIC52_RS15345	3181267..3183336	+	2070	WP_001291788.1	glycine--tRNA ligase subunit beta	-
-	3183554..3183608	-	55	-	-	Antitoxin
PIC52_RS15350	3183658..3183810	+	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
PIC52_RS15355	3183787..3183858	-	72	WP_212734107.1	hypothetical protein	-
PIC52_RS15360	3183998..3184210	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
PIC52_RS15365	3184491..3184781	-	291	WP_000455798.1	HTH-type transcriptional regulator	-
PIC52_RS15370	3185215..3185925	+	711	WP_000190516.1	DUF3053 domain-containing protein	-
PIC52_RS15375	3185975..3186949	-	975	WP_001606406.1	glyoxylate/hydroxypyruvate reductase GhrB	-
PIC52_RS15380	3187053..3187712	-	660	WP_000747625.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T267942 WP_001135731.1 NZ_CP116100:3183658-3183810 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 55 bp

>AT267942 NZ_CP116100:c3183608-3183554 [Escherichia coli]
GTTCAAGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin