Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2119537..2119795 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PIC52_RS10385 Protein ID WP_000809168.1
Coordinates 2119643..2119795 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2119537..2119594 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS10370 2115365..2116624 - 1260 WP_001606794.1 hypothetical protein -
PIC52_RS10375 2116753..2118246 - 1494 WP_001173016.1 sulfatase-like hydrolase/transferase -
PIC52_RS10380 2118267..2119028 - 762 WP_001274833.1 outer membrane protein OmpK -
- 2119537..2119594 - 58 - - Antitoxin
PIC52_RS10385 2119643..2119795 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
PIC52_RS10390 2119899..2121029 - 1131 WP_001118473.1 molecular chaperone DnaJ -
PIC52_RS10395 2121118..2123034 - 1917 WP_000516135.1 molecular chaperone DnaK -
PIC52_RS10400 2123406..2123810 + 405 WP_001606793.1 DUF2541 family protein -
PIC52_RS10405 2123836..2124549 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T267939 WP_000809168.1 NZ_CP116100:2119643-2119795 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT267939 NZ_CP116100:c2119594-2119537 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References