Detailed information of TA system TA026783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 3145366..3145955
• Replicon: chromosome
• Accession: NC_017445
• Organism: Erwinia sp. Ejp617

Toxin (Protein)

• Gene name: doc
• Uniprot ID: E3DFV5
• Locus tag: EJP617_RS14500
• Protein ID: WP_014538918.1
• Coordinates: 3145584..3145955 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: E3DFV4
• Locus tag: EJP617_RS14495
• Protein ID: WP_014544276.1
• Coordinates: 3145366..3145587 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP617_RS18965	3141135..3141344	+	210	WP_012668130.1	glycine zipper 2TM domain-containing protein	-
EJP617_RS14470	3141459..3141935	+	477	WP_014544270.1	GNAT family N-acetyltransferase	-
EJP617_RS14475	3141942..3142253	-	312	WP_041474511.1	hypothetical protein	-
EJP617_RS14480	3142318..3142757	+	440	Protein_2824	acetyltransferase	-
EJP617_RS14485	3142849..3143598	+	750	WP_014544274.1	5'-nucleotidase, lipoprotein e(P4) family	-
EJP617_RS14490	3143680..3145152	-	1473	WP_041474512.1	catalase	-
EJP617_RS14495	3145366..3145587	+	222	WP_014544276.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EJP617_RS14500	3145584..3145955	+	372	WP_014538918.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
EJP617_RS14505	3146282..3146629	-	348	Protein_2829	hypothetical protein	-
EJP617_RS14510	3147152..3149089	+	1938	WP_014544278.1	methyl-accepting chemotaxis protein	-
EJP617_RS14515	3149231..3149866	+	636	WP_014544279.1	carbonic anhydrase	-
EJP617_RS14520	3149955..3150404	-	450	WP_014544280.1	DUF4385 domain-containing protein	-
EJP617_RS19845	3150391..3150546	-	156	WP_014544281.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3132599..3149089	16490

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13521.52 Da
• Isoelectric Point: 6.6389

>T26783 WP_014538918.1 NC_017445:3145584-3145955 [Erwinia sp. Ejp617]
MINFLTSEDIIGIHERMIVAYGGLAGYADPGRIESMATRILNRHMYEGEVDIYVLAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPSHEELAVAAAQGSLDVWHIAEALKQSA

Nucleotide

• Length: 372 bp

>T26783 NC_017445:3145584-3145955 [Erwinia sp. Ejp617]
ATGATCAATTTTCTAACCAGTGAAGACATCATCGGCATTCATGAGCGTATGATAGTCGCTTACGGAGGTCTTGCCGGTTA
TGCTGATCCTGGTCGGATAGAAAGTATGGCAACACGAATTCTGAACCGCCACATGTACGAAGGCGAGGTTGATATATACG
TTCTGGCTGCTGCATATCTGCTGGCCATCGCGCGGGGGCATTGTTTCAATGATGCAAACAAGAGAACCGCATTTGCTTCG
ACGGCATTATTCCTGCGCCGTAATGGGATTCTTCTTCGGTTTTCTCCAAGCCATGAAGAGTTGGCTGTCGCAGCAGCGCA
GGGGAGCCTGGATGTATGGCATATTGCTGAAGCACTAAAACAGTCTGCATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8196.36 Da
• Isoelectric Point: 7.0094

>AT26783 WP_014544276.1 NC_017445:3145366-3145587 [Erwinia sp. Ejp617]
MQAINFTTARNELASVLDSVASGKPVMITRRSAKPVIVIDAGQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Nucleotide

• Length: 222 bp

>AT26783 NC_017445:3145366-3145587 [Erwinia sp. Ejp617]
ATGCAAGCTATAAATTTTACAACAGCCCGTAATGAACTGGCATCCGTTCTTGATAGCGTTGCCAGCGGTAAGCCAGTAAT
GATCACACGCAGATCGGCAAAGCCCGTTATTGTGATTGATGCCGGGCAGTATGAAAAAATGCAAAAGATTCAGGCCGAAT
CGGACTTTGATTGGTTGTTTACTGAACATGGGCAGACACTTGAGGCTCTTAAGAACCGATGA

Structures

Toxin

• AlphaFold DB: E3DFV5

Antitoxin

• AlphaFold DB: E3DFV4