Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2271..2830 Replicon plasmid pDETEC43
Accession NZ_CP116068
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag PID00_RS26640 Protein ID WP_000421257.1
Coordinates 2555..2830 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag PID00_RS26635 Protein ID WP_001178089.1
Coordinates 2271..2555 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS26630 (PID00_26630) 494..1366 + 873 WP_021561185.1 incFII family plasmid replication initiator RepA -
PID00_RS26635 (PID00_26635) 2271..2555 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
PID00_RS26640 (PID00_26640) 2555..2830 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PID00_RS26645 (PID00_26645) 2936..3148 + 213 WP_016237858.1 hypothetical protein -
PID00_RS26650 (PID00_26650) 3380..3646 - 267 WP_016237857.1 hypothetical protein -
PID00_RS26655 (PID00_26655) 3784..4386 - 603 WP_048966960.1 ProQ/FINO family protein -
PID00_RS26660 (PID00_26660) 4740..6086 + 1347 WP_001132021.1 protein YagA -
PID00_RS26665 (PID00_26665) 6629..6931 - 303 WP_001245884.1 hypothetical protein -
PID00_RS26670 (PID00_26670) 6928..7554 - 627 WP_000587689.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..98708 98708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T267771 WP_000421257.1 NZ_CP116068:2555-2830 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT267771 WP_001178089.1 NZ_CP116068:2271-2555 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References