Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4838481..4839160 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag PID00_RS23920 Protein ID WP_000057523.1
Coordinates 4838481..4838783 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag PID00_RS23925 Protein ID WP_000806442.1
Coordinates 4838819..4839160 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS23900 (4833744) 4833744..4834964 - 1221 WP_096122201.1 fosmidomycin MFS transporter -
PID00_RS23905 (4835182) 4835182..4836834 + 1653 WP_027662559.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
PID00_RS23910 (4836871) 4836871..4837350 - 480 WP_000186638.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
PID00_RS23915 (4837554) 4837554..4838348 - 795 WP_000365161.1 TraB/GumN family protein -
PID00_RS23920 (4838481) 4838481..4838783 + 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PID00_RS23925 (4838819) 4838819..4839160 + 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
PID00_RS23930 (4839218) 4839218..4841722 - 2505 WP_096122200.1 copper-exporting P-type ATPase CopA -
PID00_RS23935 (4841985) 4841985..4842917 + 933 WP_000883040.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4838481..4848664 10183


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T267769 WP_000057523.1 NZ_CP116067:4838481-4838783 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT267769 WP_000806442.1 NZ_CP116067:4838819-4839160 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References