267669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 39153..39700 Replicon plasmid unnamed1
Accession NZ_CP116036
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag PGH49_RS25210 Protein ID WP_001384452.1
Coordinates 39153..39431 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag PGH49_RS25215 Protein ID WP_032291093.1
Coordinates 39431..39700 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS25185 (34282) 34282..34584 + 303 WP_001245884.1 hypothetical protein -
PGH49_RS25190 (35083) 35083..36429 - 1347 WP_063118133.1 protein YagA -
PGH49_RS25195 (36782) 36782..37384 + 603 WP_000517687.1 ProQ/FINO family protein -
PGH49_RS25200 (37440) 37440..37949 + 510 WP_032291091.1 hypothetical protein -
PGH49_RS25205 (38265) 38265..39113 - 849 WP_032291092.1 3'-5' exonuclease -
PGH49_RS25210 (39153) 39153..39431 - 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
PGH49_RS25215 (39431) 39431..39700 - 270 WP_032291093.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PGH49_RS25220 (39755) 39755..39913 - 159 WP_038349023.1 hypothetical protein -
PGH49_RS25225 (40611) 40611..41642 - 1032 WP_000907863.1 plasmid replication initiator RepA -
PGH49_RS25230 (42600) 42600..42878 + 279 WP_219065241.1 ash family protein -
PGH49_RS25235 (42796) 42796..43083 + 288 WP_000074849.1 conjugal transfer protein TraA -
PGH49_RS25240 (43525) 43525..44058 + 534 WP_001306770.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..82920 82920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T267669 WP_001384452.1 NZ_CP116036:c39431-39153 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT267669 WP_032291093.1 NZ_CP116036:c39700-39431 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A0S0ZPX5

References