Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3607646..3608264 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PGH49_RS17965 Protein ID WP_001291435.1
Coordinates 3608046..3608264 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PGH49_RS17960 Protein ID WP_000344800.1
Coordinates 3607646..3608020 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS17950 (3602735) 3602735..3603928 + 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PGH49_RS17955 (3603951) 3603951..3607100 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
PGH49_RS17960 (3607646) 3607646..3608020 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PGH49_RS17965 (3608046) 3608046..3608264 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PGH49_RS17970 (3608437) 3608437..3608988 + 552 WP_000102539.1 maltose O-acetyltransferase -
PGH49_RS17975 (3609104) 3609104..3609574 + 471 WP_000136192.1 YlaC family protein -
PGH49_RS17980 (3609738) 3609738..3611288 + 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PGH49_RS17985 (3611330) 3611330..3611683 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PGH49_RS17995 (3612062) 3612062..3612373 + 312 WP_000409908.1 MGMT family protein -
PGH49_RS18000 (3612404) 3612404..3612976 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267653 WP_001291435.1 NZ_CP116035:3608046-3608264 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267653 WP_000344800.1 NZ_CP116035:3607646-3608020 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References