Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4567888..4568504 Replicon chromosome
Accession NZ_CP115874
Organism Enterobacter hormaechei subsp. steigerwaltii strain WYTS.MG41

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PBS85_RS21540 Protein ID WP_017382676.1
Coordinates 4567888..4568259 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag PBS85_RS21545 Protein ID WP_015569912.1
Coordinates 4568262..4568504 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBS85_RS21525 (PBS85_21525) 4565388..4566290 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
PBS85_RS21530 (PBS85_21530) 4566287..4566922 + 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
PBS85_RS21535 (PBS85_21535) 4566919..4567848 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
PBS85_RS21540 (PBS85_21540) 4567888..4568259 - 372 WP_017382676.1 type II toxin-antitoxin system VapC family toxin Toxin
PBS85_RS21545 (PBS85_21545) 4568262..4568504 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
PBS85_RS21550 (PBS85_21550) 4568703..4569623 + 921 WP_265188251.1 alpha/beta hydrolase -
PBS85_RS21555 (PBS85_21555) 4569632..4570573 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
PBS85_RS21560 (PBS85_21560) 4570618..4571055 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
PBS85_RS21565 (PBS85_21565) 4571052..4571933 - 882 WP_003861949.1 virulence factor BrkB family protein -
PBS85_RS21570 (PBS85_21570) 4571927..4572526 - 600 WP_003861947.1 glucose-1-phosphatase -
PBS85_RS21575 (PBS85_21575) 4572645..4573445 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T267456 WP_017382676.1 NZ_CP115874:c4568259-4567888 [Enterobacter hormaechei subsp. steigerwaltii]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT267456 WP_015569912.1 NZ_CP115874:c4568504-4568262 [Enterobacter hormaechei subsp. steigerwaltii]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References