Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4444206..4444810 Replicon chromosome
Accession NZ_CP115874
Organism Enterobacter hormaechei subsp. steigerwaltii strain WYTS.MG41

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag PBS85_RS20985 Protein ID WP_071788668.1
Coordinates 4444625..4444810 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag PBS85_RS20980 Protein ID WP_023295606.1
Coordinates 4444206..4444610 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBS85_RS20965 (PBS85_20965) 4439746..4440564 - 819 WP_026094331.1 helix-turn-helix domain-containing protein -
PBS85_RS20970 (PBS85_20970) 4440790..4442190 + 1401 WP_023304613.1 MFS transporter -
PBS85_RS20975 (PBS85_20975) 4442201..4444150 + 1950 WP_271139033.1 glycoside hydrolase family 127 protein -
PBS85_RS20980 (PBS85_20980) 4444206..4444610 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PBS85_RS20985 (PBS85_20985) 4444625..4444810 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
PBS85_RS20990 (PBS85_20990) 4445060..4446598 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
PBS85_RS20995 (PBS85_20995) 4446765..4447649 + 885 WP_015572761.1 ROK family protein -
PBS85_RS21000 (PBS85_21000) 4447653..4449491 - 1839 WP_227448262.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T267455 WP_071788668.1 NZ_CP115874:c4444810-4444625 [Enterobacter hormaechei subsp. steigerwaltii]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT267455 WP_023295606.1 NZ_CP115874:c4444610-4444206 [Enterobacter hormaechei subsp. steigerwaltii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References