Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 1682674..1683471 Replicon chromosome
Accession NZ_CP115874
Organism Enterobacter hormaechei subsp. steigerwaltii strain WYTS.MG41

Toxin (Protein)


Gene name KacT Uniprot ID A0A222RDD1
Locus tag PBS85_RS07845 Protein ID WP_032647926.1
Coordinates 1682950..1683471 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag PBS85_RS07840 Protein ID WP_015570876.1
Coordinates 1682674..1682943 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBS85_RS07805 (PBS85_07805) 1678388..1679269 + 882 WP_032670171.1 DUF6402 family protein -
PBS85_RS07810 (PBS85_07810) 1679266..1679697 + 432 WP_050594728.1 DUF6201 family protein -
PBS85_RS07815 (PBS85_07815) 1679850..1679951 + 102 Protein_1513 type VI secretion system lipoprotein TssJ -
PBS85_RS07820 (PBS85_07820) 1680175..1680402 - 228 WP_032670920.1 YccJ family protein -
PBS85_RS07825 (PBS85_07825) 1680421..1681017 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
PBS85_RS07830 (PBS85_07830) 1681408..1681578 + 171 WP_001273664.1 general stress protein -
PBS85_RS07835 (PBS85_07835) 1681695..1682600 + 906 WP_032653183.1 DMT family transporter -
PBS85_RS07840 (PBS85_07840) 1682674..1682943 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
PBS85_RS07845 (PBS85_07845) 1682950..1683471 + 522 WP_032647926.1 GNAT family N-acetyltransferase Toxin
PBS85_RS07850 (PBS85_07850) 1683530..1684852 - 1323 WP_032670921.1 pyrimidine utilization transport protein G -
PBS85_RS07855 (PBS85_07855) 1684874..1685365 - 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
PBS85_RS07860 (PBS85_07860) 1685378..1685968 - 591 WP_017693662.1 malonic semialdehyde reductase -
PBS85_RS07865 (PBS85_07865) 1685978..1686778 - 801 WP_023296287.1 pyrimidine utilization protein D -
PBS85_RS07870 (PBS85_07870) 1686786..1687172 - 387 WP_015570870.1 pyrimidine utilization protein C -
PBS85_RS07875 (PBS85_07875) 1687184..1687873 - 690 WP_032670922.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19451.21 Da        Isoelectric Point: 7.4318

>T267445 WP_032647926.1 NZ_CP115874:1682950-1683471 [Enterobacter hormaechei subsp. steigerwaltii]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT267445 WP_015570876.1 NZ_CP115874:1682674-1682943 [Enterobacter hormaechei subsp. steigerwaltii]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A222RDD1

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References