Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1174112..1174661 Replicon chromosome
Accession NZ_CP115874
Organism Enterobacter hormaechei subsp. steigerwaltii strain WYTS.MG41

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PBS85_RS05490 Protein ID WP_023296064.1
Coordinates 1174112..1174393 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0D7L8S0
Locus tag PBS85_RS05495 Protein ID WP_015571209.1
Coordinates 1174374..1174661 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBS85_RS05470 (PBS85_05470) 1169227..1170198 + 972 WP_015571213.1 LacI family DNA-binding transcriptional regulator -
PBS85_RS05475 (PBS85_05475) 1170199..1171443 - 1245 WP_015571212.1 mechanosensitive ion channel family protein -
PBS85_RS05480 (PBS85_05480) 1171511..1172947 - 1437 WP_032652875.1 MFS transporter -
PBS85_RS05485 (PBS85_05485) 1173055..1173924 + 870 WP_045357441.1 helix-turn-helix transcriptional regulator -
PBS85_RS05490 (PBS85_05490) 1174112..1174393 + 282 WP_023296064.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PBS85_RS05495 (PBS85_05495) 1174374..1174661 + 288 WP_015571209.1 helix-turn-helix transcriptional regulator Antitoxin
PBS85_RS05500 (PBS85_05500) 1174698..1175351 - 654 WP_003858884.1 oxygen-insensitive NAD(P)H nitroreductase -
PBS85_RS05505 (PBS85_05505) 1175472..1175840 - 369 WP_003858883.1 MmcQ/YjbR family DNA-binding protein -
PBS85_RS05510 (PBS85_05510) 1175830..1176420 - 591 WP_003858882.1 TetR/AcrR family transcriptional regulator -
PBS85_RS05515 (PBS85_05515) 1176612..1177715 + 1104 WP_045349906.1 RomA family MBL fold metallo-hydrolase -
PBS85_RS05520 (PBS85_05520) 1177748..1178089 + 342 WP_032670430.1 RamA family antibiotic efflux transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-83)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-87)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10931.84 Da        Isoelectric Point: 10.8507

>T267444 WP_023296064.1 NZ_CP115874:1174112-1174393 [Enterobacter hormaechei subsp. steigerwaltii]
MPAGVQAKLIRQLDKLRNNPTVLREPDSKPLPNGLFEIRTVGLIHTRGIYVYQRERTIFLLRVFIKKTQKTPSAELRLAL
KRQQEMLDEQKDY

Download         Length: 282 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10861.41 Da        Isoelectric Point: 7.1670

>AT267444 WP_015571209.1 NZ_CP115874:1174374-1174661 [Enterobacter hormaechei subsp. steigerwaltii]
MSKKIIDWDELRAELLSDSEVQASFDAEERKERLREMLAQWRNHAGLTRAQVAERMGVSAPTVSRMEANITRASLDTLTR
YALVCGVKHPQITLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7L8S0

References