Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 310589..311185 Replicon chromosome
Accession NZ_CP115874
Organism Enterobacter hormaechei subsp. steigerwaltii strain WYTS.MG41

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag PBS85_RS01485 Protein ID WP_023315213.1
Coordinates 310883..311185 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PBS85_RS01480 Protein ID WP_032672198.1
Coordinates 310589..310876 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBS85_RS01475 (PBS85_01475) 308961..310592 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
PBS85_RS01480 (PBS85_01480) 310589..310876 - 288 WP_032672198.1 putative addiction module antidote protein Antitoxin
PBS85_RS01485 (PBS85_01485) 310883..311185 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PBS85_RS01490 (PBS85_01490) 311383..312255 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
PBS85_RS01495 (PBS85_01495) 312256..312528 - 273 WP_017382612.1 DUF3811 domain-containing protein -
PBS85_RS01500 (PBS85_01500) 312579..313523 - 945 WP_032672119.1 ketopantoate/pantoate/pantothenate transporter PanS -
PBS85_RS01505 (PBS85_01505) 313617..314966 - 1350 WP_006810501.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T267442 WP_023315213.1 NZ_CP115874:c311185-310883 [Enterobacter hormaechei subsp. steigerwaltii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10088.51 Da        Isoelectric Point: 4.7045

>AT267442 WP_032672198.1 NZ_CP115874:c310876-310589 [Enterobacter hormaechei subsp. steigerwaltii]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAEALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure

References