Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 73694..74356 Replicon chromosome
Accession NZ_CP115874
Organism Enterobacter hormaechei subsp. steigerwaltii strain WYTS.MG41

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PBS85_RS00345 Protein ID WP_265188151.1
Coordinates 73958..74356 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PBS85_RS00340 Protein ID WP_047050676.1
Coordinates 73694..73954 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBS85_RS00315 (PBS85_00315) 68911..70032 - 1122 WP_271139042.1 efflux RND transporter periplasmic adaptor subunit -
PBS85_RS00320 (PBS85_00320) 70180..70749 - 570 WP_000104919.1 TetR/AcrR family transcriptional regulator -
PBS85_RS00325 (PBS85_00325) 70935..71354 + 420 WP_017383664.1 GNAT family N-acetyltransferase -
PBS85_RS00330 (PBS85_00330) 71351..71998 - 648 WP_006812486.1 TetR/AcrR family transcriptional regulator -
PBS85_RS00335 (PBS85_00335) 72092..73576 + 1485 WP_017693997.1 MDR family MFS transporter -
PBS85_RS00340 (PBS85_00340) 73694..73954 + 261 WP_047050676.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PBS85_RS00345 (PBS85_00345) 73958..74356 + 399 WP_265188151.1 type II toxin-antitoxin system VapC family toxin Toxin
PBS85_RS00350 (PBS85_00350) 74546..75346 + 801 WP_020480549.1 lipoprotein NlpA -
PBS85_RS00355 (PBS85_00355) 75380..76060 - 681 WP_032646710.1 EAL domain-containing protein -
PBS85_RS00360 (PBS85_00360) 76136..76756 - 621 WP_015570093.1 LuxR C-terminal-related transcriptional regulator -
PBS85_RS00365 (PBS85_00365) 77297..77962 + 666 WP_072134581.1 LuxR C-terminal-related transcriptional regulator -
PBS85_RS00370 (PBS85_00370) 77969..79033 - 1065 WP_271139043.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14688.81 Da        Isoelectric Point: 5.5038

>T267441 WP_265188151.1 NZ_CP115874:73958-74356 [Enterobacter hormaechei subsp. steigerwaltii]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITVCAWDSEAAATYGE
LRAAMEKKGNVMGDLDQLIAAHAISRGSTIVTNDHAFGMVQDLTVEDWTTVA

Download         Length: 399 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10084.38 Da        Isoelectric Point: 9.6899

>AT267441 WP_047050676.1 NZ_CP115874:73694-73954 [Enterobacter hormaechei subsp. steigerwaltii]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKARHRDNFLRMLKETHVPDTFLSKEERNQSYTTR
NPLEGL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References